Alcohol vs Chlorhexidine Skin Prep: What's the Difference?

Skin prep before injecting reduces the risk of introducing surface bacteria. Two common options: plain alcohol wipes, and dual-action alcohol-plus-chlorhexidine wipes. Here's the difference.

Isopropyl alcohol (70%)

The everyday standard. Alcohol prep pads are fast-acting, evaporate cleanly, and are inexpensive enough to use generously. 70% concentration is the sweet spot for antiseptic action. Ideal for routine site cleaning.

Alcohol + chlorhexidine

Dual-action wipes combine 70% alcohol with chlorhexidine gluconate. Alcohol acts fast; chlorhexidine keeps working after it dries, giving longer-lasting antiseptic coverage. Products like the Reynard alcohol + chlorhexidine pads are widely used for professional and hospital-grade skin prep.

Which to stock

Many clinics keep both: plain alcohol pads for volume routine use, and dual-action wipes where a stronger, longer-acting prep is preferred. Let the solution dry fully before injecting — wet prep stings and reduces effect.

Don't forget the rest

Prep is one step. Pair with gloves, gauze, and bandages, and always finish by disposing of sharps in a compliant container.

General information for professional purchasers, not medical advice. Products are supplied as equipment for external use per manufacturer instructions; supplied for legitimate professional, clinical, and personal medical use only.